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Navigate: FAQ Home Page > Drugs & Addiction > Pills and alcohol
Zoloft is an antidepressant, and alcohol is a depressant, so it can counter the effects of the Zoloft. It's not a good idea to mix them.
Vicodin is a depressant, so it has an added effect when taken with alcohol so you can become dangerously sleepy/sedated. Flexeril is a muscle relaxant and so is alcohol, so you can be especially clumsy when the two are taken together. Ambien is a sedative and so is alcohol, so when taken together you can become dangerously sedated/sleepy. Crushing medicines and snorting them is also dangerous, since you get fast blood absorption through the nose and high doses.
I wonder if you have a substance abuse problem, given the questions you are asking. I would recommend getting some help to evaluate and control this.
Meg Durbin , M.D.