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You can also mix equal amounts of Milk of Magnesia and Benadryl Allergy liquid. After it's mixed, you can swish a teaspoonful in your mouth for about 1 minute and then spit it out. Make sure to spit it out. If you do this every 4 to 6 hours, your canker sores may hurt less.
If your canker sores are large, last longer than 2 weeks or are so sore that you can't eat or drink, you should make an appointment to see your doctor. You should make an appointment with your doctor, too, if you also have a fever or feel sick when you have canker sores. Tell your doctor if you have canker sores more than 3 times a year.
Elizabeth Ancheta , M.D.