Main content Nadolol

    Nadolol



    Drug Information

    Nadolol is used to treat both Reference angina pectoris (chest pain) and Reference high blood pressure, and it is in a class of drugs known as beta-adrenergic blockers. Since nadolol is related to Reference propranolol, it may have similar interactions with dietary supplements and herbs.

    Common brand names:

    Corgard

    Summary of Interactions with Vitamins, Herbs, & Foods

    Reference What Are Nutrient Interactions
    Types of interactions: Beneficial Adverse Check

    Replenish Depleted Nutrients

    • none

    Reduce Side Effects

    • none

    Support Medicine

    • none

    Reduces Effectiveness

    • Reference Calcium

      Calcium supplements, if taken at the same time as some beta-blocker drugs, may reduce blood levels of the drug.1 However, whether calcium affects nadolol in this manner is unknown. Until more information is available, people on nadolol should take calcium supplements an hour before or two hours after the drug.

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
    • Reference White Willow

      The active compound in willow (Salix alba), salicin, is converted to salicylic acid in the body. Taking salicylates with other beta-adrenergic blocking drugs has resulted in decreased absorption of the drugs.2 Therefore, until more is known about the interaction between willow and nadolol, they should not be taken at the same time.

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

    Potential Negative Interaction

    • Reference Pleurisy Root

      As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.3

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
    • Reference Potassium

      People taking nadolol may experience significant increases in blood levels of potassium,4 though it is unknown whether supplementation with potassium might enhance this effect. People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of high-potassium foods, such as fruit (e.g., bananas), unless directed to do so by their doctor.

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

    Explanation Required 

    • none

    The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

    References

    1. Burnham TH, ed. Cardiovascular Agents, Antiadrenergics/Sympatholytics, Beta-Adrenergic Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 2000, 467–79.

    2. Burnham TH, ed. Cardiovascular Agents, Antiadrenergics/Sympatholytics, Beta-Adrenergic Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 2000, 467–79.

    3. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.

    4. Wheeldon NM, McDevitt DG, Lipworth BJ. The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade. Br J Clin Pharmacol 1994;38:103–8.

    Last Review: 11-07-2012

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    The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.



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