Gonadotropin-Releasing Hormone Agonist (GnRH-a) Therapy for Endometriosis

Like all hormone therapies and surgery for endometriosis, GnRH-a therapy does not cure the disease.

Up to 90% of women report full or partial pain relief after 6 months of GnRH-a therapy. Treatment also shrinks endometriosis implants in about 90% of women.^{Reference 2}

GnRH-a therapy after surgery can extend pain relief by preventing the growth of new or returning endometriosis.^{Reference 3}

Pain recurrence

After GnRH-a treatment, or any other hormone therapy, endometriosis pain can return.^{Reference 2}

• Each year, up to 20% of all women treated will have pain return after hormone treatment.
• About 37% of women who use hormone therapy for mild endometriosis have pain 5 years later.
• About 74% of women who use hormone therapy for severe endometriosis have pain 5 years later.

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