Main content Proton Pump Inhibitors (PPIs) for Peptic Ulcer Disease

    Proton Pump Inhibitors (PPIs) for Peptic Ulcer Disease



    How Well It Works

    Proton pump inhibitors (PPIs) can block more than 90% of stomach acid production. These medicines work better than antacids or H2 blockers to prevent and treat ulcers.

    Most ulcers heal within 4 weeks, although some people may need up to 4 more weeks of treatment to complete healing. In rare cases, large ulcers need even longer treatment.

    These medicines have been shown to help prevent ulcers and problems from ulcers (such as bleeding) in people who take NSAIDs long-term.Reference 1



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