Gonadotropin-Releasing Hormone Analogue (GnRH-A) Therapy
Examples
gonadotropin-releasing hormone analogue (GnRH-a)
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- Leuprolide is injected into a muscle (intramuscularly) once a month. It is also available in a dose that lasts for 3 months.
- Nafarelin is sprayed into the nose (intranasally) twice a day.
- Goserelin (3.6 mg pellet) is injected under the skin of the abdomen (subcutaneously) once every 28 days. The pellet is gradually absorbed by the body.
Gonadotropin-releasing hormone analogue (GnRH-a) therapy is approved for the treatment of endometriosis and uterine fibroids. A GnRH-a is rarely used for dysfunctional uterine bleeding.
To avoid long-term side effects, GnRH-a therapy is usually taken for only 3 to 6 months.
| By: | Reference Healthwise Staff | Last Revised: May 14, 2012 |
| Medical Review: | Reference Sarah Marshall, MD - Family Medicine
Reference Divya Gupta, MD - Obstetrics and Gynecology, Gynecologic Oncology |
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