Nausea or vomiting. You may
be able to decrease these side effects by taking your medicine with a meal and
a full glass of water.
Fluid retention and swelling, especially around the
But some TKIs, such as sunitinib, may cause serious liver problems, including liver failure.
Taking dasatinib may increase your risk for pulmonary arterial hypertension (PAH), a rare but serious heart problem.
Tyrosine kinase inhibitors may cause
depression in some people. If you have symptoms of
depression or thoughts of suicide while you are taking it, talk to your doctor
See Drug Reference for a full list of side effects.
(Drug Reference is not available in all systems.)
What To Think About
Each of the TKIs have specific ways they need to be taken, so talk with your doctor about how to take your medicine.
If imatinib or dasatinib does not work for you, your doctor may treat you with nilotinib.
Tyrosine kinase inhibitors should be used only under
the supervision of a
medical oncologist or
hematologist. He or she will monitor your blood counts
You may not be able to become pregnant or father a
child after taking this drug. Talk about this with your doctor before starting
Tyrosine kinase inhibitors can cause birth defects. Do not use this drug
if you are pregnant or wish to become pregnant or to father a child while you
are taking it. Do not breast-feed while you are taking this drug.
These medicines can interact with many other drugs. Be sure that your doctor
knows all the prescription and
over-the-counter drugs you are taking.
your tyrosine kinase inhibitor becomes less effective over time, your doctor may increase your dose,
prescribe it along with another drug, or try other drugs to treat your
Do not take tyrosine kinase inhibitors with grapefruit juice. Grapefruit
juice can make these medicines useless.
How this information was developed to help you make better health decisions.