Zollinger-Ellison Syndrome and Peptic Ulcer
Zollinger-Ellison syndrome is a rare condition in which tumors called gastrinomas form in the pancreas or part of the upper small intestine (duodenum). The tumors secrete large amounts of a hormone called gastrin. Gastrin signals the stomach to produce more acid.
- At some point during their lives, 90% to 95% of people with Zollinger-Ellison syndrome develop Reference peptic ulcers Opens New Window, usually in the upper small intestine (duodenum).
- Ulcers that occur in people with this syndrome are often hard to cure but usually can be controlled with a high dose of a proton pump inhibitor.
This syndrome is extremely rare, but it may be considered as a cause when a person has severe or repeated peptic ulcers.
- Zollinger-Ellison syndrome may occur at any age, but the symptoms are more likely to appear between the ages of 30 and 60.
- In up to two-thirds of people with this syndrome, the tumors are cancerous (malignant) and may spread to the lymph nodes and liver.
The main treatment for Zollinger-Ellison syndrome is taking proton pump inhibitors and removing the tumors causing the overproduction of acid. If this surgery is successful, you will no longer need to take medicines.
|By:||Reference Healthwise Staff||Last Revised: Reference January 4, 2012|
|Medical Review:||Reference E. Gregory Thompson, MD - Internal Medicine
Reference Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology