Fifth disease is a very
common childhood illness. Adults can get it too. It is sometimes called
slapped-cheek disease because of the rash that some people get on the face.
You spread the disease by coughing and sneezing.
Fifth disease is usually a mild illness that lasts a few weeks. It can be more serious for people with weak immune systems or blood disorders, such as sickle cell disease. It can also cause problems for the baby (fetus) of a pregnant woman who gets the illness, although this isn't common.
What causes fifth disease?
Fifth disease is caused
by a virus called human parvovirus B19. (Only humans can catch and spread fifth disease. Although there are other parvoviruses that infect animals, you cannot catch these from your pet or any other animal.)
As a rule, people
can spread fifth disease only while they have flu-like symptoms and before they
get a rash. Usually, by the time the rash appears, you can no longer spread the disease to anyone else. Some people, such as those who have weak immune systems or blood disorders, may be able to spread the disease
for a longer time.
What are the symptoms?
Symptoms usually appear 2 to 3 weeks after exposure to the virus. Early symptoms are similar
to the flu—runny nose, sore throat, headache—and may be so mild that you don't
rash comes several days later, first on the face and
later over the rest of the body. It may be itchy. The rash usually fades within 5 days. For a few weeks, the rash may come
back when you are out in the sun, get too warm, or are under stress. This doesn't mean the disease is worse.
Some people also get pain in their
joints. This can last for several weeks or even
Not all people with
fifth disease get a rash or feel sick.
How is fifth disease diagnosed?
Your doctor can
diagnose fifth disease by doing a physical exam and asking questions about your
medical history. The disease is easier to diagnose if you have the
Tests aren't usually needed, but they may be done in some cases to confirm that you have fifth disease.
How is it treated?
Fifth disease usually goes away on its own. Antibiotics don't help with fifth disease, because the illness is caused by a virus, not a bacteria.
Home treatment can help with symptoms until you feel better.
Use acetaminophen (such as
Tylenol) or ibuprofen (such as Advil or Motrin) for fever, headache, or
joint pain. Follow all directions on the label. If you give medicine to your baby, follow your doctor's advice about what amount to give. Do not give aspirin to anyone younger than
20 because of the risk of
Get extra rest.
Drink plenty of fluids.
Try not to spread the illness. Wash your hands often, and stay home from school, day care, or work. (When the rash appears, you can return.)
If you are
pregnant or have a weak immune system or certain blood disorders, see your
doctor. You may need extra checkups, tests, or treatment.
The Centers for Disease Control and Prevention (CDC) is
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American Academy of Pediatrics (2009). Parvovirus B19 (Erythema infectiosum, fifth disease). In LK Pickering et al., eds., Red Book: 2009 Report of the Committee on Infectious Diseases, 28th ed., pp: 491–493. Elk Grove Village, IL: American Academy of Pediatrics.
Belazarian L, et al. (2008). Erythema infectiosum and
parvovirus B19 infection section of Exanthematous viral diseases. In K Wolff et
al., eds., Fitzpatrick's Dermatology in General Medicine, 7th ed., vol. 2, pp. 1855–1858. New York: McGraw-Hill.
Habif TP, et al. (2011). Erythema infectiosum (fifth disease). In Skin Disease: Diagnosis and Treatment, 3rd ed., pp. 295–296. Edinburgh: Saunders.
Koch WC (2011). Parvovirus B19. In RM Kliegman et al., eds., Nelson Textbook of Pediatrics, 19th ed., pp. 1094–1097. Philadelphia: Saunders.
National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Centers for Disease Control (2011). Parvovirus B19 (fifth disease). . Available online: http://www.cdc.gov/ncidod/dvrd/revb/respiratory/parvo_b19.htm.
Salvaggio H, Zaenglein A (2010). Parvovirus infection. In MG Lebwohl et al., eds., Treatment of Skin Disease: Comprehensive Therapeutic Strategies, 3rd ed., pp. 533–535. Edinburgh: Saunders Elsevier.
Primary Medical Reviewer
John Pope, MD - Pediatrics
Specialist Medical Reviewer
Thomas Emmett Francoeur, MD, MDCM, CSPQ, FRCPC - Pediatrics
How this information was developed to help you make better health decisions.