Fluorouracil (5-FU) for Genital Warts (Human Papillomavirus)
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Fluorouracil has not been approved by the U.S. Food and Drug Administration (FDA) for the treatment of Reference genital warts Opens New Window. Using fluorouracil to treat genital warts is an Reference unlabeled use Opens New Window of the medicine.
Application of 5% cream
Fluorouracil is applied 1 to 3 times a week for several weeks as needed to clear the warts. To reduce skin sensitivity, the cream can be washed off 3 to 10 hours after it is applied.
The surrounding normal tissue can be protected with petroleum jelly (such as Vaseline) or another ointment to prevent irritation. For men, the skin at the tip of the penis should be protected with an ointment.
You should not wear tight-fitting underwear, because it might smear the medicine to other areas.
A skin reaction may not occur until 3 to 4 days after the cream is applied. If the reaction is severe, you should stop treatment.
|By:||Reference Healthwise Staff||Last Revised: June 21, 2012|
|Medical Review:||Reference Sarah Marshall, MD - Family Medicine
Reference Kirtly Jones, MD - Obstetrics and Gynecology