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Sickle Cell Crisis

Topic Overview

What is a sickle cell crisis?

A sickle cell crisis is a painful episode that may begin suddenly in a person who has Reference sickle cell disease Opens New Window.

A sickle cell crisis occurs when Reference sickle-shaped red blood cells Opens New Window Reference Opens New Window clump together and block small blood vessels that carry blood to certain organs, muscles, and bones. This causes mild to severe pain. The pain can last from hours to days. "Painful event" and "painful crisis" are other terms used to describe these episodes. Some people who have sickle cell disease have many painful events, while others have few or none.

The pain can happen in any part of the body. But the most common areas include the:

Bones of the spine.
Bones in the arms and legs.
Chest.
Abdomen.

How is it treated?

Treatment depends on the level of pain and how long it lasts. Sometimes, nonprescription, or Reference over-the-counter Opens New Window, pain relievers such as ibuprofen can help. Other times, a person needs stronger pain relief medicine that is prescribed or given by a doctor. Some painful episodes may need Reference IV Opens New Window therapy for fluids and powerful pain medicines, such as morphine, to ease the pain.

You can prepare for a crisis in advance by creating a pain management plan with your doctor. This plan should include not only the types of medicines you can take at home but also other actions you can take at home to relieve pain. Also, your plan helps you know when to call your doctor or go to a hospital.

For more information, see Reference Sickle Cell Disease: Pain Management.

How can you prevent a crisis?

It isn't always possible to know what sets off a crisis, but triggers include Reference dehydration Opens New Window, cold temperatures, infection, stress, and low oxygen intake.

You can help prevent a crisis by:

Drinking plenty of fluids, especially before, during, and after exercise or strenuous activity and when you have a fever or infection. Drink enough so that your urine is light yellow or clear like water.
Dressing warmly in cold weather. Try to avoid situations where you might become cold. Exposure to cold air, wind, and water may cause a crisis by triggering red blood cell sickling in exposed areas of the body.
Exercise with care. If you exercise strenuously, rest when you feel tired, and drink plenty of fluids to prevent dehydration. Dehydration and reduced oxygen levels in a person's blood resulting from strenuous exercise may cause red blood cells to sickle.
Get plenty of sleep.
Try to reduce and manage stress in your life.

For more information, see Reference Sickle Cell Disease: Staying Healthy.

By:	Reference Healthwise Staff	Last Revised: Reference October 1, 2012
Medical Review:	Reference E. Gregory Thompson, MD - Internal Medicine Reference Martin Steinberg, MD - Hematology