Main content

    HealthWise KnowledgeBase

    Misoprostol for Abortion

    Misoprostol for Abortion



    Side Effects

    This method of abortion causes symptoms similar to a Reference miscarriage Opens New Window (such as severe cramping and vaginal bleeding) as tissue and clots pass from the uterus. Symptoms may include:

    • Nausea.
    • Vomiting.
    • Diarrhea.
    • Headache.
    • Dizziness.
    • Chills or hot flushes (sweating and feeling overly hot).
    • Shivering.
    • Fatigue.

    The U.S. Food and Drug Administration (FDA) has reported that a few women have died from a severe infection (Reference sepsis) after having an abortion using mifepristone and vaginal misoprostol.Reference 4 Signs of serious infection include weakness, nausea, and diarrhea with or without belly pain. This rare infection may not cause a fever. Call your doctor or go to the hospital if you have any of these signs of a serious infection after having a medical abortion.

    Signs of complications

    Call your doctor immediately if you have any of these symptoms after an abortion:

    • Severe bleeding. Both medical and surgical abortions usually cause bleeding that is different from a normal menstrual period. Severe bleeding can mean:
      • Passing clots that are bigger than a golf ball, lasting 2 or more hours.
      • Soaking more than 2 large pads in an hour, for 2 hours in a row.
      • Bleeding heavily for 12 hours in a row.
    • Signs of infection in your whole body, such as headache, muscle aches, dizziness, or a general feeling of illness. Severe infection is possible without fever.
    • Severe pain in the belly that is not relieved by pain medicine, rest, or heat
    • Hot flushes or a fever of 100.4°F (38°C) or higher that lasts longer than 4 hours
    • Vomiting lasting more than 4 to 6 hours
    • Sudden belly swelling or rapid heart rate
    • Vaginal discharge that has increased in amount or smells bad
    • Pain, swelling, or redness in the genital area

    Call your doctor for an appointment if you have had any of these symptoms after a recent abortion:

    • Bleeding (not spotting) for longer than 2 weeks
    • New, unexplained symptoms that may be caused by medicines used in your treatment
    • No menstrual period within 6 weeks after the procedure
    • Signs and symptoms of Reference depression Opens New Window. Hormonal changes after a pregnancy can cause depression that requires treatment.

    See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)



    This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Reference Terms of Use. Reference How this information was developed to help you make better health decisions.