Antibody Tests for Lupus
- Anti-dsDNA (antibodies to DNA).
- Antinuclear antibody (Reference ANA)
- Anti-Smith (Sm).
- Anti-SS-A (also called Ro).
- Anti-SS-B (also called La).
These antibody tests are often positive in lupus and can provide support for a diagnosis if the clinical criteria are unclear or if the ANA test is negative but lupus is strongly suspected.
- Anti-SS-A (Ro) and anti-SS-B (La) antibodies are not specific for lupus and are found commonly in Reference Sjögren's syndrome Opens New Window. But these tests are useful in helping women with lupus who are considering pregnancy. If a woman who has these antibodies becomes pregnant, she may need more careful monitoring of the fetus, since these antibodies are associated with a higher risk of the baby being born with neonatal lupus syndrome or a heart defect called congenital heart block.
- High titers of anti-dsDNA are usually seen only in people who have lupus.
- A positive anti-Sm test is a specific marker for lupus.
Anti-dsDNA tests can be repeated at intervals to monitor how the disease is progressing.
|By:||Reference Healthwise Staff||Last Revised: Reference May 10, 2012|
|Medical Review:||Reference Anne C. Poinier, MD - Internal Medicine
Reference Nancy Ann Shadick, MD, MPH - Internal Medicine, Rheumatology