Antidepressants for Hot Flashes
How It Works
Selective serotonin reuptake inhibitors (SSRIs) affect the brain's use of a Reference neurotransmitter Opens New Window chemical called serotonin, which is thought to have a role in regulating body heat. Increased serotonin use by the brain can also improve Reference perimenopausal Opens New Window mood swings and irritability.
Venlafaxine affects the brain's serotonin and norepinephrine levels. How it affects hot flashes is not known. Mood may also improve with venlafaxine use.